PBPKPlus™
What is the PBPKPlus™ Module?
Ranked as the #1 PBPK software for In Vitro-In Vivo Extrapolation (IVIVE) & PBPK modeling by Pfizer!
(Cole et al., 2nd Asian Pacific Regional ISSX Meeting, May 2008, Shanghai, China)
NEW! Improved handling of covariates in Population Simulator.
NEW! Additional disease physiology groups (obesity, renal impairment)
NEW! Clearance mechanisms in blood compartments
Upgraded! Infant PBPK models – easily perform pediatric PBPK modeling to capture the pharmacokinetics and pharmacodynamics in infants as young as 16 weeks premature, with automatic scaling of physiological parameters (e.g., hematocrit, plasma protein levels) with age!
Want to see the PBPKPlus Module in action? Take a look at some recent posters focused on pediatric PBPK simulations. More applications can be seen while visiting the DDI Module page or our Resource Center.
Resources
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Prediction of Acyclovir Pharmacokinetics in Pediatric Populations using a Physiologically Based Pharmocokinetic (PBPK) Model
Learn MoreTo develop a PBPK model for acydovir incorporating processes affecting the drug's absorption and distribution after i.v. administration of acydovir (ACV) as well as it's in vivo formulation after...
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Physiologically Based Pharmacokinetic (PBPK) Model for Prediction of Vancomycin Pharmacokinetics in Children
Learn MoreEthical considerations prevent extensive clinical trials in pediatric populations; however, with the use of PBPK modeling, in vivo data from adults can be used to explore the mechanisms of drug...
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The Influence of Dissolution, PMAT Influx, and MATE Efflux Rates on Paracellular Absorption of Metformin Using a Mechanistic Oral Absorption / PBPK Model
Learn MoreA physiologically based absorption and distribution model was developed for metformin to facilitate our understanding of the influence of transporters and dissolution rate on oral absorption.
