The frequency of resistance to beta-lactams among nosocomial isolates has been increasing due to extended-spectrum beta-lactamase (ESBL)-producing enteric bacilli.
Preparation and evaluation of ibuprofen beads by melt solidification technique
A novel single step melt solidification technique was developed for ibuprofen.
Asthma features in severe alpha1-antitrypsin deficiency: experience of the National Heart, Lung, and Blood Institute Registry
To describe asthma features in a cohort with alpha(1)-antitrypsin (AAT) deficiency, and determine the impact of asthma on FEV(1) decline.
Composite solubility versus pH profile and its role in intestinal absorption prediction
The purpose of this study was to examine absorption of basic drugs as a function of the composite solubility curve and intestinally relevant pH by using a gastrointestinal tract (GIT) absorption...
Microarray analysis of host cell gene transcription in response to varicella-zoster virus infection of human T cells and fibroblasts in vitro and SCIDhu skin xenografts in vivo
During primary infection, varicella-zoster virus (VZV) is spread via lymphocytes to skin, where it induces a rash and establishes latency in sensory ganglia.
Worldwide antimicrobial susceptibility patterns and pharmacodynamic comparisons of gatifloxacin and levofloxacin against Streptococcus pneumoniae: report from the antimicrobial resistance rate epidemiology study team
The use of fluoroquinolones for the treatment of community-acquired respiratory tract infection is increasing.
Temperature variability during preparation of Shouktik Bhasma and its consequences
Development of Bhasma involves complex unit operations including Shodhana, Marana and Bhavana, which need to be optimized to avoid batch-to-batch variations.
Current trends in the treatment of upper respiratory tract infections in neonates, infants and children: A survey
Scoparone produced a rapid and sustained fall of blood pressure in anaesthetized normotensive and experimental hypertensive animals and conscious normotensive rats.
Role of Aloe vera juice treatment (Bhavana) in preparation of Shouktik Bhasma
Preparation of Shouktik Bhasma (SB) involves intermittent trituration of heated material with Aloe vera juice.
Spherical Crystallization of Celecoxib
Celecoxib exhibits poor flow properties and compressibility.
Prediction of intestinal absorption: comparative assessment of GastroPlus and IDEA
We have assessed two commercial software tools employing physiologically based models for prediction of intestinal absorption in human.
Rule Extraction from a Mutagenicity Data Set Using Adaptively Grown Phylogenetic-like Trees
A public bacterial mutagenicity database was classified into 2-D structural families using a set of specific algorithms and clustering techniques that find overlapping...
Analysis of Large Screening Data Sets via Adaptively Grown Phylogenetic-Like Trees
As the use of high-throughput screening systems becomes more routine in the drug discovery process, there is an increasing need for fast and reliable analysis of the massive...
Data Analysis of High-Throughput Screening Results: Application of Multidomain Clustering to the NCI Anti-HIV Data Set
The routine use of high-throughput screening (HTS) systems in the drug discovery process has resulted in an increasing need for fast, reliable analysis of massive amounts of data.
Rapid Assessment of Data Set Structures
When SAS® data is received from an external source, such as a sponsor, CRO, or another department, it is important to assess the new data to determine if variables have been added or removed, locate…
Pharmacodynamic considerations in the treatment of moderate to severe pseudomonal infections with cefepime
Pseudomonas aeruginosa is one of the more common and clinically difficult-to-treat causes of hospital-acquired infections.
Pharmacodynamics in the evaluation of drug regimens
We believe, especially in an era of increasing antimicrobial resistance, that the integration of PK/PD models and stochastic techniques provides a powerful new tool...
Pharmacodynamic profiling of levofloxacin and gatifloxacin using Monte Carlo simulation for community-acquired isolates of Streptococcus pneumoniae
In vitro and in vivo models of infection suggest that the area under the concentration-time curve (AUC): minimum inhibitory concentration (MIC) ratio...
A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide
Pharmacokinetic (PK) and pharmacodynamic (PD) models for azimilide were developed and validated with sparse blood sampling and QTc interval data obtained