Large Pharmaceutical Company Renews Global Software Licenses

Simulations Plus Receives Large Multi-Year Pharmaceutical Software License
Hoffmann-LaRoche Renews Multi-year Software Licenses

Pharmacodynamics of cefprozil against Haemophilus influenzae in an in vitro pharmacodynamic model
An in vitro pharmacodynamic model was used to determine the pharmacokinetic-pharmacodynamic (PK-PD) measure and magnitude most strongly related...

Simulations Plus Releases GastroPlus(™) 5.2
Flagship Software Product Improvements Provide Greater Accuracy and Convenience

Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder
A population model was developed with the aim to simultaneously describe risperidone and 9-hydroxyrisperidone pharmacokinetics; to obtain estimates for pharmacokinetic parameters and associated...

Simulations Plus Releases ClassPharmer(™) 4.2
Improvements Provide New Capabilities Requested by User Community

Simulations Plus Reports Preliminary FY2006 Financial Results
Annual Revenues Up 23%, Net Earnings Up 158%

Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract
Novel estrogenic therapies are needed that ameliorate menopausal symptoms and have the bone-sparing effects of endogenous estrogens but do not promote breast or...

Simulations Plus Announces Fiscal Year 2006 Earnings Conference Call
Conference Call to be on Thursday, November 9, at 4:15 PM EST

In Silico Prediction of Ionization
The focus of this chapter is computational methods for the prediction of aqueous ionization of organic molecules.

Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections
Tigecycline, a first-in-class expanded glycylcycline antimicrobial agent, has demonstrated efficacy in the treatment of complicated skin and skin structure infections...

Population Pharmacokinetics of (R)-Albuterol Following Inhaled Levalbuterol or Racemic Albuterol via a Hydrofluoroalkane Metered Dose Inhaler in Pediatric and Adult Asthma Patients
Levalbuterol (LEV), the (R)-enantiomer of racemic albuterol (RA), is approved for the treatment or prevention of bronchospasm in patients ≥4 years of age via metered dose inhaler (MDI). A population…

Japan’s NIHS Licenses Simulations Plus ClassPharmer Software for Five Years
National Institute of Health Sciences is Equivalent to U.S. F.D.A.

Simulations Plus Releases ADMET Predictor(™) 2.0
Powerful Predictive Software Enhanced With Superior Molecular Modeling Capabilities

Population Pharmacokinetics of Nebulized Arformoterol in Subjects with COPD
(R,R)-Formoterol (ARF) is a highly selective, potent and long-acting β2-adrenoceptor agonist currently under development in the US for the longterm maintenance treatment of bronchoconstriction associated…

Exposure-Response Relationship for Nebulized Arformoterol in Subjects with COPD
Arformoterol (ARF) is a highly selective, potent, long-acting β2-adrenoceptor agonist under development in the US for the maintenance treatment of bronchoconstriction associated with COPD. An initial…

Biorelevant dissolution media as a predictive tool for glyburide a class II drug
The purpose of this study was to predict the oral absorption of glyburide. Biorelevant dissolution methods, combined with permeability measurements and computational simulations, were used...

Simulations Plus Announces Large Consulting Contract
Company Underscores Guidance at Fiscal Year End

In Silico Modeling of Non-Linear Drug Absorption for the P-gp Substrate Talinolol and of Consequences for the Resulting Pharmacodynamic Effect
The aim of the present work was to demonstrate P-glycoprotein's involvement in the non-linear talinolol pharmacokinetics using an advanced compartment and transit model (ACAT) and to compare...