Automated Concentration-QT data preparation, model selection and reporting in R

Automated Concentration-QT data preparation, model selection and reporting in R

Authors: Bonnefois G, Cellière G, Chauvin J, Krause A
Conference: International Society of Pharmacometrics
Keywords: concentration-QTc, concentration-QTc models, MonolixSuite, non-linear mixed effect models, R package, reporting
Software: Monolix®

Since the publication of the ICH E14 guidance in 2015, QT interval prolongation as-sessment can be carried out with a concentration-QTc modeling approach as part of single- or mul-tiple- dose escalation studies, instead of conducting a thorough QT/QTc study.

mlxDesignEval: A novel R package for design evaluation based on MonolixSuite, and its comparison to popED and PFIM

mlxDesignEval: A novel R package for design evaluation based on MonolixSuite, and its comparison to popED and PFIM

Authors: Cellière G, Chauvin J, Pierre M, Twarogowska M
Conference: American Conference of Pharmacometrics
Keywords: MonolixSuite, population PK/PD
Software: Monolix®, Simulx®

Designing clinical trials to support population PK/PD modeling requires careful choices of sampling times, number of subjects, dose groups and other trial features to
ensure precise parameter estimation - with low relative standard errors [1].

Pharmacokinetic Studies and Synergistic Antitumor Effects of Cannabichromene and Cannabidiol in Drug-Resistant Breast Cancers

Pharmacokinetic Studies and Synergistic Antitumor Effects of Cannabichromene and Cannabidiol in Drug-Resistant Breast Cancers

Authors: Aare M, Padakanti SC, Bagde A, Lazarte JM, Dev S, Lewis C, Singh M
Publication: Drug Delivery and Translational Research
Keywords: antibacterial drug resistance, cancer therapeutic resistance, chemotherapy, combination drug therapy, drug therapy drugs
Software: GastroPlus®

Triple-negative breast cancer (TNBC) is highly aggressive with limited treatment options, and resistance to doxorubicin (DOX) further compromises outcomes.