Total revenue up 31% year-over-year primarily driven by strong software growth
Formulation Development and Evaluation, in silico PBPK Modeling and in vivo Pharmacodynamic Studies of Clozapine Matrix Type Transdermal Patches
Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia.
Multi-Criteria Decision Analysis in Drug Discovery
Drug discovery is inherently a multi-criteria optimization problem.
Neuropharmacological Profile of New Thiazepinone and Thiazolidinone Compounds Designed by Virtual Screening
To evaluate the neuropharmacological profile of new spiro thiazepinone and thiazolidinone compounds in CD1 mice after a computer-aided virtual screening based on a GABA-A/BZD site.
Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients
Salbutamol, a short-acting β2-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes.
Characterization of Preclinical Radio ADME Properties of ARV-471 for Predicting Human PK Using PBPK Modeling
Proteolysis-targeting chimeras (PROTACs) represent a promising class of drugs that can target disease-causing proteins more effectively than traditional small molecule inhibitors can, potentially revolutionizing drug discovery and treatment strategies.
In silico Model to Predict Dermal Absorption of Chemicals in Finite Dose Conditions
The development of in silico approaches that can estimate the dermal absorption of chemicals exposed in practical conditions is highly anticipated. In the present study, an in silico model to estimate both the dermal absorption rate and dermal permeation profile was developed for the application of chemicals in finite dose conditions.
10 Most Read Journal Articles of 2024
In an industry that’s constantly evolving, staying ahead of the curve is crucial. Every breakthrough, every new piece of research can shape the future—and if you’re not in the loop, you risk falling behind.
Advancing Systemic Toxicity Risk Assessment: Evaluation of a NAM-based Toolbox Approach
For many years, a method that allowed systemic toxicity safety assessments to be conducted without generating new animal test data, seemed out of reach.
Establishment of Biopredictive Dissolution and Bioequivalence Safe Space Using the Physiologically Based Biopharmaceutics Modeling for Tacrolimus Extended-Release Capsules
A slight variation in in vivo exposure for tacrolimus extended-release (ER) capsules, which have a narrow therapeutic index (NTI), significantly affects the pharmacodynamics of the drug. Generic drug bioequivalence (BE) standards are stricter, necessitating accurate assessment of the rate and extent of drug release.
Advancements in Ocular Modelling and Simulations: Key Considerations and Case Studies
This review paper discusses the key aspects of ocular biopharmaceutics, with emphasis on the crucial role played by ocular compartmental modelling and simulation in deciphering physiological conditions related to various eye diseases.
Modeling and Simulation of AcetaminophenPharmacokinetics and Hepatic Biomarkers After Overdosesof Extended-Release and Immediate-Release Formulationsin Healthy Adults Using the Quantitative SystemsToxicology Software Platform DILIsym
Acetaminophen (APAP) has been formulated as immediate-, modified-, and extended-release tablets (APAP-IR, -MR, and -ER,respectively).
Current State and New Horizons in Applications of Physiologically Based Biopharmaceutics Modeling (PBBM): A Workshop Report
This report summarizes the proceedings for Day 3 of the workshop titled “Physiologically Based Biopharmaceutics Modeling (PBBM) Best Practices for Drug Product Quality: Regulatory and Industry Perspectives”.
Less Coding, More Exploring: Demystifying Built-in Libraries in MonolixSuite
Does this sound familiar? You are a pharmacometric modeler facing a tight deadline.
Predicting Pharmacokinetics of Active Constituents in Spatholobi caulis by Using Physiologically Based Pharmacokinetic Models
Spatholobi Caulis (SPC) is a medicinal plant that mainly grows in China and Southeast Asian countries and commonly used in clinics; the pharmacokinetic characteristics in humans need to be determined.
De-Risking Clinical Hepatotoxicity in Early Drug Discovery
Hepatotoxicity due to drugs and other xenobiotics, also known as drug-induced liver injury (DILI), is a primary reason for 1) the termination of drug development programs, 2) the delay of approving otherwise efficacious drugs by requiring large and expensive safety-focused clinical trials, 3) the restriction on the clinical use of approved drugs by the inclusion of black box warnings, and 4) the removal of approved drugs from the market.
Physiologically Based Biopharmaceutics Modeling Coupled with Biopredictive Dissolution in Development of Bioequivalent Formulation for Mesalamine Enteric Coated Tablet: A Tough Nut to Crack
Mesalamine is a locally acting anti-inflammatory drug used to treat mild to moderate ulcerative colitis.
The Role of Carotenoids from Red Mamey Fruit (Pouteria sapota) Against Amyloid-β Monomers in Alzheimer’s Disease: Computational Analysis and ADMET Prediction
Carotenoids, potent antioxidants in fruits and vegetables, have recently garnered attention for their potential therapeutic effects against neurodegenerative diseases.
Hydrogel for Sustained Delivery of Therapeutic Agents
In recent years, hydrogels have emerged as a highly promising platform for the sustained delivery of therapeutic agents, addressing critical challenges in drug delivery systems, from controlled release to biocompatibility.