Your simulation tool for IVIVE of absorption processes…
For over 20 years, significant research has been devoted to in vitro permeability studies (e.g., Caco-2 assays), with several guidelines being published and all pharmacopeia describing appropriate methods for testing. Unfortunately, the permeability experiments are relatively expensive, and since you don’t have a lot of time or material available, how do you prioritize which compounds to test early in your project? Or, once you have identified a few promising leads, is your experimental design robust enough to capture all of the relevant information you need?
Enter MembranePlus™, the industry’s leading mechanistic in vitro permeability software. MembranePlus is helpful for:
- Users of GastroPlus™ looking to define inputs (e.g., lysosomal trapping and unbound fractions) for more accurate in vivo absorption predictions in the Advanced Compartmental Absorption and Transit (ACAT™) model
- Discovery scientists looking to categorize compounds into high and low permeability classes
- DMPK researchers that focus on in vitro transporter/metabolism kinetic studies
- CROs which provide in vitro Caco-2, PAMPA, or MDCK permeability services, to assist with the optimization of the experimental design for client studies