There is an overgrowing emphasis on supersaturating drug delivery systems (SDDS) with increase in number of poorly water-soluble compounds.
FDA Purchases Bundle of ADMET Predictor® Licenses
Center for Tobacco Products incorporates machine learning platform to assist toxicology research
Physiology Based Pharmacokinetic Modeling in Generic Drug Development and Regulatory Decisions- Opportunities & Challenges
Physiology based pharmacokinetic (PBPK) modeling is widely used within the pharmaceutical industry to predict oral drug absorption.
Determination of Dermal Pharmacokinetics by Microdialysis Sampling in Rats
The evaluation of absorption and availability at the site of action of a drug candidate is an important element of drug discovery and development, as clinical response is...
Design, synthesis and pharmacological evaluation of a novel mTOR-targeted anti-EV71 agent
Due to the limitations of existing anti-EV71 targets, we have been eager to discover a new anti-EV71 agent based on mTOR (the mammalian target of rapamycin), which is an important target for finding antiviral agents...
GastroPlus® v9.7 Release Webinar
Learn about the latest developments in GastroPlus®!
hERG Liability Classification Models Using Machine Learning Techniques
Known for its critical role in cardiac action potential repolarization, the voltage-dependent hERG K+ channel is one of the most prominent anti-targets determining cardio-toxicity of drugs.
An Efficient Strategy for the Glycosylation of Total Bufadienolides in Venenum Bufonis
Venenum Bufonis (VB), also called ChanSu or toad venom, is an important Traditional Chinese Medicine derived from the parotid gland secretion of giant toads (Bufo bufo gargarizans or Bufo melanostictus).
Reduced T-cell Numbers and Elevated Levels of Immunomodulatory Cytokines in Metastatic Prostate Cancer Patients De Novo Resistant to Abiraterone and/or Enzalutamide Therapy
Currently, there are two Food and Drug Administration (FDA)-approved drugs for androgen deprivation therapy (ADT) of metastatic castration-resistant prostate cancer...
ADMET Predictor 9.5 Release Notes
This new release of ADMET Predictor includes significant enhancements throughout the program, including to the ADMET Modeler™ and MedChem Designer™ modules.
Simulations Plus Releases ADMET Predictor® Version 9.5
New machine learning models and novel analysis methods address customer requests
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
The clinical impact of drug-drug interactions based on time-dependent inhibition of cytochrome P450 (CYP) 3A4 has often been overpredicted, likely due to use of improper inhibitor concentration estimates at the enzyme.
NAFLDsym v2A Release Webinar
NAFLDsym v2A includes mechanistic representation of fibrosis, steatosis, lipotoxicity, and inflammation. Over 1000 simulated patients with variability in their underlying pathophysiology, represent a spectrum of...
Simulations Plus Reports Record Second Quarter FY2019 Revenue
Quarterly Revenues Up 15%; Board of Directors Announces Quarterly Dividend of $0.06 Per Share
How to Understand Aqueous Ionization and Its Influence on Key Physical Properties of Drugs
Part I “You Must Unlearn What You Have Learned”: Clearing Up Myths About Aqueous Ionization of Drugs
Ocular biopharmaceutics: impact of modeling and simulation on topical ophthalmic formulation development
The estimation of ocular pharmacokinetics (PK) in various eye tissues is limited because of sampling challenges.
Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
The mechanistic target of rapamycin complex (mTORC1) is a signaling hub on the lysosome surface, responding to lysosomal amino acids.
Simulations Plus Sets Date for 2nd Quarter 2019 Earnings Release and Conference Call
Conference Call to be on Tuesday, April 9, 2019, at 4:15 PM ET