Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model.
Statement from Cognigen’s President, Jill Fiedler-Kelly
At Cognigen, we appreciate more than ever, the global community in which we live and work and the impact each of us can...
Metabolic Profiling of Nuciferine In Vivo and In Vitro
Nuciferine (NF) is one of the main constituents of Lotus (Nelumbo nucifera) leaves which have been widely used in both food and drug formulations in China.
Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria.
Relevance of Physiologically Based Biopharmaceutical Modeling (PBBM) in the Approval of Generic Products
The Webinar "Relevance of Physiologically Based Biopharmaceutical Modeling (PBBM) in the Approval of Generic Products", which will be presented in Spanish
Dose Optimization in Kidney Disease: Opportunities for PBPK Modeling and Simulation
Kidney disease affects pharmacokinetic (PK) profiles of not only renally cleared drugs but also nonrenally cleared drugs.
Model‐Informed Dose Optimization in Pregnancy
Pregnancy is associated with several physiological changes that can alter the pharmacokinetics (PK) and pharmacodynamics of drugs.
Simulations Plus Reports Fourth Quarter FY2020 Financial Results
Simulations Plus, Inc. (Nasdaq: SLP), a leading provider of modeling and simulation solutions for the pharmaceutical, biotechnology, chemicals, and consumer goods industries, today reported financial results for its 2020 fiscal year (FY20) and fourth quarter (4QFY20) ended August 31, 2020.
Novel Clinical Trial Designs for Optimizing Parameter Estimation in Malaria Disease-Drug Models
An introduction to Model-Informed Drug Development (MIDD) for Malaria and Volunteer Infection Studies (VIS)
Principles of Ensuring Data Integrity
Have you ever lost data or have someone who worked on a project leave and take their knowledge of the data with them? Stream the webinar replay by Dr. Joel Owen in collaboration with Pharmacometrics Africa.
StrategiesPlus™ COVID-19 ACT Program
According to the World Health Organization (WHO), COVID-19 has infected more than 5.45 million patients and killed more than 1.25 million people worldwide as of November 10, 2020.
Assessment of the Mechanism for Remdesivir-Associated Clinical ALT Elevations Using DILIsym Quantitative Systems Toxicology Modeling
Remdesivir, a monophosphoramidate prodrug of a nucleoside analog, has been granted Emergency Use Authorization in the U.S. for the treatment of hospitalized COVID-19 patients.
Mathematical Modeling with NAFLDsym Supports the Role of Adiponectin in the Reduction of Steatosis by the Anti-FGFR1/KLB Bispecific Antibody
The agonist anti-FGFR1/KLB bispecific antibody, BFKB8488A, has been shown to be effective at reducing liver fat in NAFLD patients in a Ph1b study [1].
Structure-activity relationship, molecular docking, and molecular dynamic studies of diterpenes from marine natural products with anti-HIV activity
HIV-1 infection is a global epidemic whose treatment is limited majorly by viral resistance and adverse effects.
In Silico Modeling as a Tool to Predict and Characterize Plant Toxicity
One of the greatest challenges encountered during the manufacture of drugs is the high level of toxicity, which can have adverse effects on the environment, humans, plants, and animals.
Development of Quantitative Systems Toxicology Model to Predict Drug Induced Acute Kidney Injury via mtDNA Depletion Pathway
Treatment of chronic viral infections like HIV, Hepatitis B etc necessitates long term administration of powerful antivirals like...
Factors Affecting Successful Extrapolation of Ibuprofen Exposure from Adults to Pediatric Populations After Oral Administration of a Pediatric Aqueous Suspension
The importance of physiologically based pharmacokinetic (PBPK) model refinement with data acquired in adults using a pediatric...