What is GastroPlus?
GastroPlus is an advanced software program that simulates the absorption, pharmacokinetics, and pharmacodynamics for drugs in human and preclinical species. The underlying model is the Advanced Compartmental Absorption and Transit (ACAT) model. Since 1997, Simulations Plus has evolved the ACAT model to a high state of refinement, providing the industry's most accurate, flexible, and powerful simulation program. This smoothly integrated platform combines a user-friendly interface with sophisticated science to help you make better project decisions... faster!
The GastroPlus simulations include:
• Whole-body physiological models for human (fasted and fed), beagle dog (fasted and fed), rat (fasted and fed), mouse (fasted and fed), and cyno monkey
• Variety of dosage forms: intravenous (bolus or infusion), immediate release (tablet, capsule, suspension, solution, lingual spray, and sublingual tablet), and controlled release (gastric retention, dispersed release, integral tablet, enteric coated tablet and capsule, and buccal patch)
• Peff converter to convert user-measured permeability to human in vivo Peff
• pH-dependent solubility and logD models
• Mechanistic effect of bile salts on
in vivo drug solubility and dissolution
• Enhanced treatment of nanoparticle effects on solubility and dissolution
• Dissolution and precipitation dependence on particle size, shape and particle density
• Chemical degradation of drug in intestinal lumen prior to absorption
• Enterohepatic circulation
• Parameter Sensitivity Analysis - test sensitivity of results to changes in any model parameters
• Virtual Trials - predict likely population distributions of PK/PD results
• Ability to fit one-, two-, or three-compartment conventional pharmacokinetic models to IV and/or oral data (with optional PKPlus Module)
• Physiologically based pharmacokinetics (with optional PBPKPlus Module)
• Automated model fitting for single or multiple data sets (with optional Optimization Module)
• Saturable metabolism and active transport in gut or other tissues (with optional Metabolism and Transporter Module)
• Advanced In Vitro - In Vivo Correlation for immediate or controlled release formulations (with optional IVIVCPlus Module)
• Structure-based predictions of biopharmaceutical parameters required for GastroPlus simulations (with optional ADMET Predictor Module)
• Pharmacodynamic modeling (PK/PD or PBPK/PD) with industry standard models
(with optional PDPlus Module)
GastroPlus
Saves Time
As pharmaceutical and biotech companies strive to reduce the enormous costs and time required to bring new drugs to market, computer tools have become an important and necessary part of drug discovery and development. From simple spreadsheets to sophisticated supercomputer molecular dynamics models, the ability of researchers to experiment in silico has become an important complement to in vitro and in vivo experimentation. GastroPlus expands state-of-the-art computer simulation into the realm of gastrointestinal absorption, pharmacokinetics, and pharmacodynamics.
Benefits of GastroPlus
• Rapid analysis and understanding of the behavior of drug candidates in animals and human.
• Understand food effects.
• Assess effects of influx and efflux transporters in gut
• Predict first-in-human/animal doses through PBPK simulation.
• Conduct virtual population studies.
• Fit complex nonlinear metabolism and transport in any tissue.
• Build PBPK/PD models with target tissue concentrations
• Track multiple metabolites (and metabolites of metabolites)
• Deconvolute in vivo dissolution for IVIVC
GastroPlus is used by more pharmaceutical researchers than any other simulation software. This includes 18 of the top 20 pharmaceutical companies in the world. You, too, can benefit from the industry's most powerful analytical capability for oral, ocular, and pulmonary absorption/pharmacokinetic/pharmacodynamics (combined with world-class support), at a fraction of the cost to develop and maintain an equivalent capability in-house.
For further information about licensing GastroPlus, please contact:
Mr. John DiBella
Director, Marketing & Sales
661-723-7723 ext. 244
john.dibella@simulations-plus.com
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